Low-Fat Diets
Adherence to a low-fat diet for at least eightyears reduces the risk of developing ovarian cancer amongpostmenopausal women by 40%, according to results from the NIH-sponsored Women’s Health Initiative Dietary Modification Trail published online Tuesday in the Journal of the National Cancer Institute, the AP/Google.com reports. According to the American Cancer Society, about 22,400 women in the U.S. will be diagnosed with ovarian cancer this year and about 15,200 will die from the disease.
For the study, Ross Prentice of the Fred Hutchinson Cancer Research Centerand colleagues tracked nearly 40,000 women ages 50 to 79, some of whomwere assigned to reduce the amount of fat in their diets from anaverage of 35% to 20%, while others maintained their normal diets(Neergaard, AP/Google.com, 10/9). The study found that after the firstfour years of the study, the two groups had similar cancer rates;however, after the next four years of the study, the intervention grouphad a rate of 0.38 cases of ovarian cancer per 1,000 women annually,compared with a rate of 0.64 cases per 1,000 women in the control group(Brown, Reuters Health, 10/9).
Thestudy also found that women in the intervention group had a 9% lowerrisk of developing breast cancer, but the finding was not large enoughto be statistically significant. According to the AP/Google.com, someresearchers have theorized that high fat intake increases the amount ofestrogen in the blood, which could play a role in the development ofovarian and breast cancer. The study found that women in theintervention group had an average 15% reduction in estradiol, a form ofestrogen, while the control group had no change. Women in the study whocut their fat intake the most experienced the greatest reduction inbreast and ovarian cancer risk, according to the study (AP/Google.com,10/9).
"The take-home message for the practicing clinician isthat encouraging postmenopausal female patients to undertake a changeto a low-fat diet likely will reduce ovarian cancer risk and may alsoreduce the risk of breast cancer and total invasive cancer," Prenticesaid (Reuters Health, 10/9).
Most Women Unaware of WHI Results, Survey Says
Most women are unaware of the results from WHI studies that have foundsignificant health risks associated with long-term hormone replacementtherapy, according to a recently released survey, HealthDay/Washington Post reports (Doheny, HealthDay/Washington Post, 10/10).
NIHresearchers in July 2002 ended the WHI study on combination HRT threeyears early because they determined that the treatment might increasethe risk for heart disease, invasive breast cancer and other healthproblems. A later WHI analysis, published in the April 4 issue of the Journal of the American Medical Association, found that HRT use among women in their 50s does not increase their risk for heart attack (Kaiser Daily Women’s Health Policy Report, 9/17).
For the survey, Randall Stafford, associate professor of medicine at Stanford University’s Prevention Research Center,and colleagues interviewed 781 women ages 40 to 60 to determine if theyknew about the study, including 252 premenopausal women, 88perimenopausal women and 227 women who were menopausal orpostmenopausal. The researchers asked: "Have you heard or read anythingabout the results of the Women’s Health Initiative, a major researchstudy in the U.S. suggesting the health risks of taking hormone therapyoutweigh the benefits for most women?"
The survey found thatonly 29% knew of the study. In addition, 40% answered more questionsabout the risks of HRT use correctly than incorrectly, and 64% knewthat hormones were thought to increase the risk of breast cancer. About36% of women who were aware of the WHI findings had talked with theirdoctors about HRT, and 15% of women who did not know about the studyresults discussed HRT with their physicians, the survey found.
Adherence to a low-fat diet for at least eightyears reduces the risk of developing ovarian cancer amongpostmenopausal women by 40%, according to results from the NIH-sponsored Women’s Health Initiative Dietary Modification Trail published online Tuesday in the Journal of the National Cancer Institute, the AP/Google.com reports. According to the American Cancer Society, about 22,400 women in the U.S. will be diagnosed with ovarian cancer this year and about 15,200 will die from the disease.
For the study, Ross Prentice of the Fred Hutchinson Cancer Research Centerand colleagues tracked nearly 40,000 women ages 50 to 79, some of whomwere assigned to reduce the amount of fat in their diets from anaverage of 35% to 20%, while others maintained their normal diets(Neergaard, AP/Google.com, 10/9). The study found that after the firstfour years of the study, the two groups had similar cancer rates;however, after the next four years of the study, the intervention grouphad a rate of 0.38 cases of ovarian cancer per 1,000 women annually,compared with a rate of 0.64 cases per 1,000 women in the control group(Brown, Reuters Health, 10/9).
Thestudy also found that women in the intervention group had a 9% lowerrisk of developing breast cancer, but the finding was not large enoughto be statistically significant. According to the AP/Google.com, someresearchers have theorized that high fat intake increases the amount ofestrogen in the blood, which could play a role in the development ofovarian and breast cancer. The study found that women in theintervention group had an average 15% reduction in estradiol, a form ofestrogen, while the control group had no change. Women in the study whocut their fat intake the most experienced the greatest reduction inbreast and ovarian cancer risk, according to the study (AP/Google.com,10/9).
"The take-home message for the practicing clinician isthat encouraging postmenopausal female patients to undertake a changeto a low-fat diet likely will reduce ovarian cancer risk and may alsoreduce the risk of breast cancer and total invasive cancer," Prenticesaid (Reuters Health, 10/9).
Most Women Unaware of WHI Results, Survey Says
Most women are unaware of the results from WHI studies that have foundsignificant health risks associated with long-term hormone replacementtherapy, according to a recently released survey, HealthDay/Washington Post reports (Doheny, HealthDay/Washington Post, 10/10).
NIHresearchers in July 2002 ended the WHI study on combination HRT threeyears early because they determined that the treatment might increasethe risk for heart disease, invasive breast cancer and other healthproblems. A later WHI analysis, published in the April 4 issue of the Journal of the American Medical Association, found that HRT use among women in their 50s does not increase their risk for heart attack (Kaiser Daily Women’s Health Policy Report, 9/17).
For the survey, Randall Stafford, associate professor of medicine at Stanford University’s Prevention Research Center,and colleagues interviewed 781 women ages 40 to 60 to determine if theyknew about the study, including 252 premenopausal women, 88perimenopausal women and 227 women who were menopausal orpostmenopausal. The researchers asked: "Have you heard or read anythingabout the results of the Women’s Health Initiative, a major researchstudy in the U.S. suggesting the health risks of taking hormone therapyoutweigh the benefits for most women?"
The survey found thatonly 29% knew of the study. In addition, 40% answered more questionsabout the risks of HRT use correctly than incorrectly, and 64% knewthat hormones were thought to increase the risk of breast cancer. About36% of women who were aware of the WHI findings had talked with theirdoctors about HRT, and 15% of women who did not know about the studyresults discussed HRT with their physicians, the survey found.
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